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BACKGROUND: Apolipoprotein (APOE) epsilon4 allele has been associated with cardiac dysfunction in Alzheimer's disease and beta-thalassemia. We investigated the association between APOE genotypes and left ventricular dysfunction in a population of community-dwelling elderly subjects. METHODS: This study was performed in the Rotterdam Study, a population-based prospective cohort study among elderly subjects. For 2206 participants, a baseline echocardiogram and blood specimens for APOE typing were available. Cardiac dysfunction was considered present when fractional shortening was or=65 years. CONCLUSION: The APOE epsilon4 allele is an independent risk factor for cardiac dysfunction in elderly people. Besides well-known effects on atherosclerosis and cholesterol levels, there may be other mechanisms, such as apoptosis, through which this allele exerts negative effects on myocardial performance.

Original publication




Journal article


Am Heart J

Publication Date





685 - 689


Age Factors, Aged, Alleles, Apolipoprotein E3, Apolipoprotein E4, Apolipoproteins E, Case-Control Studies, Cohort Studies, Female, Genotype, Heart Diseases, Humans, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Risk Factors, Ventricular Dysfunction, Left