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For the identification of genes associated with smoking initiation and current smoking, genome-wide association analyses were carried out in 3497 subjects. Significant genes that replicated in three independent samples (n = 405, 5810, and 1648) were visualized into a biologically meaningful network showing cellular location and direct interaction of their proteins. Several interesting groups of proteins stood out, including glutamate receptors (e.g., GRIN2B, GRIN2A, GRIK2, GRM8), proteins involved in tyrosine kinase receptor signaling (e.g., NTRK2, GRB14), transporters (e.g., SLC1A2, SLC9A9) and cell-adhesion molecules (e.g., CDH23). We conclude that a network-based genome-wide association approach can identify genes influencing smoking behavior.

Original publication

DOI

10.1016/j.ajhg.2009.02.001

Type

Journal article

Journal

Am J Hum Genet

Publication Date

03/2009

Volume

84

Pages

367 - 379

Keywords

Adult, Cell Adhesion Molecules, Female, Genome-Wide Association Study, Humans, Male, Middle Aged, Protein Binding, Receptor Protein-Tyrosine Kinases, Receptors, Glutamate, Signal Transduction, Smoking, Smoking Cessation