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Anionic phospholipids are minor but prominent components of the plasma membrane that are necessary for ion channel function. Their persistence in bulk membranes, in particular phosphatidylinositol 4,5-bisphosphate (PIP2), initially suggested they act as channel cofactors. However, recent technologies have established an emerging system of nanoscale signaling to ion channels based on lipid compartmentalization (clustering), direct lipid binding, and local lipid dynamics that allow cells to harness lipid heterogeneity to gate ion channels. The new tools to study lipid binding are set to transform our view of the membrane and answer important questions surrounding ion channel-delimited processes such as mechanosensation.

Original publication

DOI

10.1016/j.tibs.2019.04.001

Type

Journal article

Journal

Trends Biochem Sci

Publication Date

03/05/2019

Keywords

cryo-electron microscopy, lipid rafts, mass spectrometry, signaling lipids, super-resolution imaging