Contact information
robin.choudhury@cardiov.ox.ac.uk
+44 (0)1865 234664
Miss Eunice Berry
eunice.berry@cardiov.ox.ac.uk
Colleges
Websites
-
British Heart Foundation Alumni Reflections Series
Professor Choudhury interviewed by BHF Associate Medical Director Professor James Leiper
-
Balliol College Lectures: A Cultural History through depictions of the Heart; Botticelli to Banksy
Professor Choudhury in discussion with Dr Jennifer Sliwka, Keeper of Western Art, Ashmolean Museum
The Beating Heart.
Robin Choudhury
MA DM FRCP
Professor of Cardiovascular Medicine
- Honorary Consultant Cardiologist
- Fellow in Biomedical Sciences, Balliol
Integrative Physiology (Systems Biology)
Overview
BACKGROUND:
Robin Choudhury qualified in medicine at the University of Oxford with postgraduate training in London (Royal Brompton & Hammersmith) and at Mount Sinai School of Medicine, New York. He is Professor of Cardiovascular Medicine at the University of Oxford; Consultant Cardiologist to the John Radcliffe Hospital and Research Fellow in Biomedical Sciences at Balliol. He is an Affiliated Researcher at the Institute of Regenerative Medicine.
He is co-PI of of the NovoNordisk Foundation supported Metabolite-related inflammation and disease (MeRIAD) consortium; Joint clinical lead in the MRC-BHF Centre of Research Excellence in Advanced Cardiac Therapies (REACT) and UK Chief Investigator for the ZEUS clinical trial of Ziltivekimab.
RESEARCH:
His translational science laboratory aims to understand how cells of the innate immune system are involved in processes of tissue homeostasis, injury and repair.
Areas of particular interest focus around: (1) understanding the role of monocytes, macrophages and neutrophils in acute myocardial infarction; myocardial regeneration vs repair and in atherosclerosis and (2) how bone marrow stem cells are 'programmed' e.g. by extracellular vesicles and through by genetic / epigenetic and metabolic mechanisms. The laboratory has a particular interest in hyperglycaemia-induced trained immunity.
CLINICAL PRACTICE:
Professor Choudhury has a specialist clinical interest in coronary artery disease and its management. He has particular expertise in the assessment and optimisation of cardiovascular risk factors and their interactions (e.g. cholesterol; diabetes; 'inflammation' and genetic risk).
Key publications
-
Inflammatory processes in cardiovascular disease: a route to targeted therapies.
Journal article
Ruparelia N. et al, (2017), Nat Rev Cardiol, 14, 133 - 144
-
Heart regeneration and repair after myocardial infarction: translational opportunities for novel therapeutics
Journal article
(2018), Nature Reviews Drug Discovery
-
Acute myocardial infarction activates distinct inflammation and proliferation pathways in circulating monocytes, prior to recruitment, and identified through conserved transcriptional responses in mice and humans.
Journal article
Ruparelia N. et al, (2015), Eur Heart J, 36, 1923 - 1934
-
Endothelium-derived extracellular vesicles promote splenic monocyte mobilization in myocardial infarction.
Journal article
Akbar N. et al, (2017), JCI insight, 2
-
Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.
Journal article
Edgar L. et al, (2021), Circulation
Recent publications
-
Benchmarking Photon-Counting Computed Tomography Angiography Against Invasive Assessment of Coronary Stenosis: Implications for Severely Calcified Coronaries.
Journal article
Kotronias RA. et al, (2025), JACC Cardiovasc Imaging
-
Deep learning based coronary vessels segmentation in X-ray angiography using temporal information
Journal article
He H. et al, (2025), Medical Image Analysis, 103496 - 103496
-
Impact of soluble thrombomodulin and activated protein C on dynamic hemostatic function in trauma: a focus on thrombin generation and clot lysis.
Journal article
Curry NS. et al, (2025), Haematologica, 110, 414 - 424
-
Single-Source Domain Generalization for Coronary Vessels Segmentation in X-Ray Angiography
Chapter
Atwany M. et al, (2025), Lecture Notes in Computer Science, 1 - 11
-
Cardiovascular Magnetic Resonance Before Invasive Coronary Angiography in Suspected Non-ST-Segment Elevation Myocardial Infarction.
Journal article
Shanmuganathan M. et al, (2024), JACC Cardiovasc Imaging, 17, 1044 - 1058
-
Stratification of acute myocardial and endothelial cell injury, salvage index and final infarct size by systematic microRNA profiling in acute ST-elevation myocardial infarction.
Journal article
Dawkins S. et al, (2024), Coron Artery Dis, 35, 122 - 134
-
Multi-organ single-cell RNA sequencing in mice reveals early hyperglycemia responses that converge on fibroblast dysregulation.
Journal article
Braithwaite AT. et al, (2024), FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 38
-
Patient-specific in silico 3D coronary model in cardiac catheterisation laboratories.
Journal article
Lashgari M. et al, (2024), Front Cardiovasc Med, 11
-
Trained immunity in diabetes and hyperlipidemia: Emerging opportunities to target cardiovascular complications and design new therapies.
Journal article
Robinson KA. et al, (2023), FASEB J, 37
-
Lipid-associated macrophages transition to an inflammatory state in human atherosclerosis, increasing the risk of cerebrovascular complications (vol 2, pg 656, 2023)
Journal article
Dib L. et al, (2023), NATURE CARDIOVASCULAR RESEARCH, 2, 794 - 794