MA PhD FRS FMedSci
Statutory Professor of Pharmacology
- Wellcome Trust Senior Investigator
- Professorial Fellow of Lady Margaret Hall
- Extraordinary Lecturer in Biochemical Pharmacology, New College
I was educated at Trinity College, Cambridge, and received a BA in Natural Sciences (pharmacology part 2) in 1985 and my PhD (zoology) in 1989, having worked on the role of calcium oscillations in cell activation in Sir Michael Berridge's laboratory.
After a short spell at UCL working on mammalian fertilisation with Michael Whitaker, I went to Johns Hopkins University as a Harkness Fellow studying the role of calcium signals in early development. Returning to the UK in 1991, I joined the Department of Pharmacology. I have been successively a Beit Memorial Fellow, Wellcome Trust Career Development Fellow and Wellcome Trust Senior Fellow in Basic Biomedical Research.
I was elected to a Tutorial Fellowship at New College in 1998 in conjunction with a proleptic University appointment, appointed to a titular Professor of Pharmacology in 2002, and elected to the Professorship of Pharmacology and a Professorial Fellowship at LMH in 2006. I was Head of the Department of Pharmacology from 2006-2015.
I received the 2001 Novartis Prize of the British Pharmacological Society for my scientific contributions to pharmacology. I became a Fellow of the Academy of Medical Sciences in 2010 for my contributions to the advancement of medical science, and in 2016 I was elected a Fellow of The Royal Society for my work on calcium signalling.
NAADP-regulated two-pore channels drive phagocytosis through endo-lysosomal Ca2+ nanodomains, calcineurin and dynamin.
Davis LC. et al, (2020), EMBO J
Pyridine Nucleotide Metabolites and Calcium Release from Intracellular Stores
Galione A. and Chuang KT., (2020), Advances in experimental medicine and biology, 1131, 371 - 394
Galione A., (2019), Cold Spring Harb Perspect Biol
A multiscale analysis in CD38-/- mice unveils major prefrontal cortex dysfunctions.
Martucci LL. et al, (2019), FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 33, 5823 - 5835
Characterization of ADP-ribosyl cyclase 1-like (ARC1-like) activity and NAADP signaling during slow muscle cell development in zebrafish embryos.
Kelu JJ. et al, (2019), Dev Biol, 445, 211 - 225