Websites
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Sponsor: British Heart Foundation
Learning about silent genes that could help the heart repair itself
Joaquim Miguel Vieira
PhD
Academic Visitor
- Lecturer in Cardiovascular Medicine and BHF Research Fellow at King's College London
Joaquim Vieira studied Biochemistry as an undergraduate at the University of Lisbon, Portugal, and researched developmental angiogenesis for his PhD in Professor Christiana Ruhrberg's laboratory at University College London (UCL). After successful postdoctoral studies at UCL and University of Oxford with Professor Paul Riley investigating the epigenetic regulation of the epicardium and role of cardiac lymphatics during heart development and disease, he was awarded a British Heart Foundation (BHF) Intermediate Basic Science Research Fellowship to start his research group in Oxford.
The Vieira group studies the role of long noncoding RNAs and enhancers during epithelial-to-mesenchymal transition in the developing and diseased heart; and retains an interest in understanding cell-cell interactions in the developing heart supporting coronary and lymphatic vasculature expansion, as well as patterning of the cardiac autonomic system. A better understanding of the cellular and molecular mechanisms supporting organ development is poised to identify molecular targets to effect (adult) heart repair.
Dr Vieira is now an Academic Visitor at DPAG, visiting from King's College London where he is a Lecturer in Cardiovascular Medicine and BHF Research Fellow.
Previous University of Oxford College affiliations
October 2018 - September 2019: (non-stipendiary) Lecturer in Medicine at St. Hilda's College
October 2013 - October 2015: (non-stipendiary) Fulford Junior Research Fellow at Somerville College
Key publications
BRG1-SWI/SNF-dependent regulation of the Wt1 transcriptional landscape mediates epicardial activity during heart development and disease
Journal article
Vieira JMN. et al, (2017), Nature Communications
Characterisation of the human embryonic and foetal epicardium during heart development.
Journal article
Risebro CA. et al, (2015), Development, 142, 3630 - 3636
Cardiac lymphatics are heterogeneous in origin and respond to injury.
Journal article
Klotz L. et al, (2015), Nature, 522, 62 - 67
Recent publications
Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development.
Preprint
Zhao J. et al, (2025)
Endothelial Slit2 guides the Robo1-positive sympathetic innervation during heart development
Journal article
Zhao J. et al, (2025), eLife, 14
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration.
Journal article
Gamen E. et al, (2025), Elife, 14
Stabilisation of HIF signalling in the mouse epicardium extends embryonic potential and neonatal heart regeneration
Journal article
Gamen E. et al, (2025), eLife, 14
Cardiac lymphatics retain LYVE-1-dependent macrophages during neonatal mouse heart regeneration.
Journal article
Chapman BG. et al, (2025), Nat Cardiovasc Res, 4, 1258 - 1276
Stabilisation of HIF signalling extends epicardial activation and neonatal heart regeneration
Preprint
Gamen E. et al, (2025)