BSc (Hons), PhD
Associate Professor of Cardiovascular Biochemistry
- British Heart Foundation Intermediate Basic Science Research Fellow
Mark Crabtree is a British Heart Foundation Intermediate Basic Science Research Fellow and became a Group Leader and University Research Lecturer within the Division of Cardiovascular Medicine in 2015. His research group focuses on understanding the mechanisms of nitric oxide and redox signalling in molecular models of cardiovascular disease.
He began his postdoctoral research with Professor Keith Channon in 2006 and he held an internal University of Oxford British Heart Foundation Centre of Research Excellence Transition Fellowship (2012-2015). Mark did a collaborative PhD with the University of Surrey and Weill Medical College of Cornell University in New York City, having completed his BSc at the University of Surrey in 2001.
His research interests focus on metabolomic and proteomic approaches to understand the impact of redox alterations in molecular and mouse models of cardiovascular homeostasis and disease.
Nitric oxide modulates metabolic remodelling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation
CRABTREE M. et al, (2019), Cell Reports
Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.
Svistunova DM. et al, (2019), Free Radic Biol Med, 130, 151 - 162
Regulation of Mycobacterial Infection by Macrophage Gch1 and Tetrahydrobiopterin
MCNEILL E. et al, (2018), Nature Communications
Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation
CRABTREE M. et al, (2018), Scientific Reports
Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.
Douglas G. et al, (2018), Cardiovasc Res, 114, 1385 - 1399