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Mehroz Ehsan, a DPhil student working with Katja Gehmlich and Charles Redwood, and Matthew Kelly, a postdoc working with Houman Ashrafian and Hugh Watkins, have used a newly-generated mouse model to study the consequences of Muscle LIM protein mutations leading to Hypertrophic Cardiomyopathy.

The work, which is a collaboration with scientists at King's College London and the University of California San Diego, has shed light into disease mechanisms: protein depletion leads to lack of functional Muscle LIM protein and induces a proteotoxic response in the heart.

The research was led by Katja Gehmlich, BHF Intermediate Fellow in the Division of Cardiovascular Medicine and also involved collaborators at the Wellcome Trust Centre for Human Genetics. The article can be accessed here.