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Dilated Cardiomyopathy Mutations in Thin Filament Regulatory Proteins Reduce Contractility, Suppress Systolic Ca2+ & Activate NFAT & AKT Signalling

Journal article

Robinson P. et al, (2020), American Journal of Physiology-Heart and Circulatory Physiology

Mavacamten rescues increased myofilament calcium sensitivity and dysregulation of Ca2+ flux caused by thin filament hypertrophic cardiomyopathy mutations.

Journal article

Sparrow AJ. et al, (2020), American journal of physiology. Heart and circulatory physiology