BHF Senior Basic Science Research Fellow
Duncan Sparrow completed his PhD at the University of Adelaide in the nineties in the field of the regulation of tissue-specific transcription. He moved to the National Institute for Medical Research in Mill Hill for his first postdoc, where he worked with Dr Tim Mohun on the developmental biology of heart and skeletal muscle formation in Xenopus laevis. He then returned to Australia to take up the position of Senior Research Scientist in Professor Sally Dunwoodie's laboratory at the Victor Chang Cardiac Research Institute. There he investigated the genetic and environmental causes of congenital vertebral malformation in human patients and mouse models.
His current research focus is how embryonic heart development can be perturbed by both genetic and environmental means. He is supported by funding from the British Heart Foundation, Novo Nordisk, The John Fell Fund and the Federated Foundation.
Moreau JLM. et al, (2019), Development, 146, dev172957 - dev172957
NAD Deficiency, Congenital Malformations and Niacin Supplementation
Shi H. et al, (2017), New England Journal of Medicine
Gestational Stress Induces the Unfolded Protein Response Resulting in Heart Defects
Shi H. et al, (2016), Development
Sparrow DB. et al, (2012), Cell, 149, 295 - 306