Genetic loci influencing kidney function and chronic kidney disease.
Chambers JC., Zhang W., Lord GM., van der Harst P., Lawlor DA., Sehmi JS., Gale DP., Wass MN., Ahmadi KR., Bakker SJL., Beckmann J., Bilo HJG., Bochud M., Brown MJ., Caulfield MJ., Connell JMC., Cook HT., Cotlarciuc I., Davey Smith G., de Silva R., Deng G., Devuyst O., Dikkeschei LD., Dimkovic N., Dockrell M., Dominiczak A., Ebrahim S., Eggermann T., Farrall M., Ferrucci L., Floege J., Forouhi NG., Gansevoort RT., Han X., Hedblad B., Homan van der Heide JJ., Hepkema BG., Hernandez-Fuentes M., Hypponen E., Johnson T., de Jong PE., Kleefstra N., Lagou V., Lapsley M., Li Y., Loos RJF., Luan J., Luttropp K., Maréchal C., Melander O., Munroe PB., Nordfors L., Parsa A., Peltonen L., Penninx BW., Perucha E., Pouta A., Prokopenko I., Roderick PJ., Ruokonen A., Samani NJ., Sanna S., Schalling M., Schlessinger D., Schlieper G., Seelen MAJ., Shuldiner AR., Sjögren M., Smit JH., Snieder H., Soranzo N., Spector TD., Stenvinkel P., Sternberg MJE., Swaminathan R., Tanaka T., Ubink-Veltmaat LJ., Uda M., Vollenweider P., Wallace C., Waterworth D., Zerres K., Waeber G., Wareham NJ., Maxwell PH., McCarthy MI., Jarvelin M-R., Mooser V., Abecasis GR., Lightstone L., Scott J., Navis G., Elliott P., Kooner JS.
Using genome-wide association, we identify common variants at 2p12-p13, 6q26, 17q23 and 19q13 associated with serum creatinine, a marker of kidney function (P = 10(-10) to 10(-15)). Of these, rs10206899 (near NAT8, 2p12-p13) and rs4805834 (near SLC7A9, 19q13) were also associated with chronic kidney disease (P = 5.0 x 10(-5) and P = 3.6 x 10(-4), respectively). Our findings provide insight into metabolic, solute and drug-transport pathways underlying susceptibility to chronic kidney disease.