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Mass spectrometry of intact membrane protein complexes requires removal of the detergent micelle by collisional activation. We demonstrate that the necessary energy can be obtained by adjusting the degree of collisional cooling in the ion source. This enables us to extend the energy regime for dissociation of membrane protein complexes.

Original publication

DOI

10.1039/c5cc07045g

Type

Journal article

Journal

Chem Commun (Camb)

Publication Date

04/11/2015

Volume

51

Pages

15582 - 15584

Keywords

Gases, Mass Spectrometry, Membrane Proteins, Protein Unfolding, Thermodynamics