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Publications

Acetylation turns leucine into a drug by membrane transporter switching.

Churchill GC. et al, (2021), Sci Rep, 11

Adenosine integrates light and sleep signalling for the regulation of circadian timing in mice

JAGANNATH A. et al, (2021), Nature Communications

A master protocol to investigate a novel therapy acetyl-L-leucine for three ultra-rare neurodegenerative diseases: Niemann-Pick type C, the GM2 Gangliosidoses, and Ataxia Telangiectasia

Fields T. et al, (2020)

Acetylation of L-leucine switches its carrier from the L-amino acid transporter (LAT) to organic anion transporters (OAT)

Churchill G. et al, (2020)

Unexpected differences in the pharmacokinetics of N-acetyl-DL-leucine enantiomers after oral dosing and their clinical relevance

Churchill G. et al, (2019)

Ebselen has lithium-like effects on central 5-HT2A receptor function.

Antoniadou I. et al, (2018), Br J Pharmacol, 175, 2599 - 2610

The putative lithium-mimetic ebselen reduces impulsivity in rodent models.

Barkus C. et al, (2018), Journal of psychopharmacology (Oxford, England), 269881118784876 - 269881118784876

Plasma glutathione suggests oxidative stress is equally present in early and late onset bipolar disorder

Goodwin GM. et al, (2018), Bipolar Disorders

Iron overload causes endolysosomal deficits modulated by NAADP-regulated 2-pore channels and RAB7A.

Fernández B. et al, (2016), Autophagy, 12, 1487 - 1506

Effects of the potential lithium-mimetic, ebselen, on impulsivity and emotional processing.

Masaki C. et al, (2016), Psychopharmacology, 233, 2655 - 2661

Effect of the Putative Lithium Mimetic Ebselen on Brain Myo-Inositol, Sleep, and Emotional Processing in Humans.

Singh N. et al, (2016), Neuropsychopharmacology, 41, 1768 - 1778

The Inositol-3-Phosphate Synthase Biosynthetic Enzyme Has Distinct Catalytic and Metabolic Roles.

Frej AD. et al, (2016), Mol Cell Biol, 36, 1464 - 1479

Oxford Lithium Trial (OxLith) of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorder: study protocol for a randomised controlled trial.

Saunders KEA. et al, (2016), Trials, 17

Effects of the potential lithium-mimetic, ebselen, on brain neurochemistry: a magnetic resonance spectroscopy study at 7 tesla.

Masaki C. et al, (2016), Psychopharmacology (Berl), 233, 1097 - 1104

Oxford Lithium Trial (OxLith): a randomised, double-blind placebo-controlled study of the early affective, cognitive, neural and biochemical effects of lithium carbonate in bipolar disorde

Geddes JR. et al, (2016), Trials

Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.

Kilpatrick BS. et al, (2016), Cell Calcium, 59, 12 - 20

Two-pore Channels (TPC2s) and Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) at Lysosomal-Sarcoplasmic Reticular Junctions Contribute to Acute and Chronic β-Adrenoceptor Signaling in the Heart.

Capel RA. et al, (2015), J Biol Chem, 290, 30087 - 30098

Release of calcium from endolysosomes increases calcium influx through N-type calcium channels: Evidence for acidic store-operated calcium entry in neurons.

Hui L. et al, (2015), Cell Calcium, 58, 617 - 627

Determining the CNS effects of ebselen: a potential lithium-mimetic

Singh N. et al, (2015), EUROPEAN NEUROPSYCHOPHARMACOLOGY, 25, S406 - S406

Nicotinic Acid Adenine Dinucleotide Phosphate (NAADP) and Endolysosomal Two-pore Channels Modulate Membrane Excitability and Stimulus-Secretion Coupling in Mouse Pancreatic β Cells.

Arredouani A. et al, (2015), J Biol Chem, 290, 21376 - 21392

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