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Publications

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine.

CRABTREE M. et al, (2021), Biochemical Society Transactions

Itaconate as an inflammatory mediator and therapeutic target in cardiovascular medicine.

DIOTALLEVI M. et al, (2021), Biochemical Society Transactions

Hepatic miR-144 drives fumarase activity preventing NRF2 activation during obesity.

Azzimato V. et al, (2021), Gastroenterology

Hyperglycaemia Induces Trained Immunity in Macrophages and Their Precursors and Promotes Atherosclerosis.

Edgar L. et al, (2021), Circulation

Endothelial GTP Cyclohydrolase and Tetrahydrobiopterin Regulate Gestational Blood Pressure, Uteroplacental Remodeling and Fetal Growth

CHUAIPHICHAI S. et al, (2021), Hypertension

Atrial nitroso-redox balance and refractoriness following on-pump cardiac surgery: A randomised trial of atorvastatin.

Jayaram R. et al, (2020), Cardiovasc Res

Nitric oxide modulates metabolic remodelling in inflammatory macrophages through TCA cycle regulation and itaconate accumulation

CRABTREE M. et al, (2019), Cell Reports

Oxidation resistance 1 regulates post-translational modifications of peroxiredoxin 2 in the cerebellum.

Svistunova DM. et al, (2019), Free Radic Biol Med, 130, 151 - 162

Regulation of Mycobacterial Infection by Macrophage Gch1 and Tetrahydrobiopterin

MCNEILL E. et al, (2018), Nature Communications

Tetrahydrobiopterin modulates ubiquitin conjugation to UBC13/UBE2N and proteasome activity by S-nitrosation

CRABTREE M. et al, (2018), Scientific Reports

Roles for endothelial cell and macrophage Gch1 and tetrahydrobiopterin in atherosclerosis progression.

Douglas G. et al, (2018), Cardiovasc Res, 114, 1385 - 1399

Effects Of Endothelin-1 On Intracellular Tetrahydrobiopterin Levels In Vascular Tissue.

Cerrato R. et al, (2018), Scandinavian cardiovascular journal : SCJ, 1 - 7

A Key Role for Tetrahydrobiopterin-Dependent Endothelial NOS Regulation in Vascular Resistance Arteries: Studies in Endothelial Cell Tetrahydrobiopterin-Deficient Mice

Chuaiphichai S. et al, (2017), British Journal of Pharmacology

A Novel Role for Endothelial Tetrahydrobiopterin in Mitochondrial Redox Balance

Bailey JD. et al, (2017), Free Radical Biology and Medicine

Protection against ventricular fibrillation via cholinergic receptor stimulation and the generation of nitric oxide.

Kalla M. et al, (2016), The Journal of Physiology, 594, 3981 - 3992

Mildly compromised tetrahydrobiopterin cofactor biosynthesis due to Pts variants leads to unusual body fat distribution and abdominal obesity in mice.

Korner G. et al, (2016), J Inherit Metab Dis, 39, 309 - 319

Uncoupled Inducible Nitric Oxide Synthase Influences Macrophage Polarization In Acute Lung Injury

Golden T. et al, (2016), AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, 193

Homoarginine Supplementation Improves Cardiac Function in a Murine Model of Ischaemic Heart Failure

Atzler D. et al, (2015), CIRCULATION, 132

CAPON modulates neuronal calcium handling and cardiac sympathetic neurotransmission during dysautonomia in hypertension.

Lu C-J. et al, (2015), Hypertension, 65, 1288 - 1297

Parkinson's disease in GTP cyclohydrolase 1 mutation carriers.

Ryan BJ. et al, (2015), Brain, 138

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