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Aim 2. Conditioning the injury environment

  1. Identification of pro-regenerative versus pro-fibrotic molecular signatures of functionally defined subsets of immune cells- specific focus on macrophages
  2. Generation of therapeutic modulators of inflammation- proof-of-principle on use of evasins to target multiple chemokines post-MI
  3. Targeting pro-inflammatory immune cell recruitment and chemotaxis via exosome-microRNA cargo using antagomiRs
  4. Therapeutic augmentation of lymphangiogenesis for immune cell trafficking: lead candidate development of chemical inducers of coronary lymphatic vessels post-MI and inflammatory cell resolution
  5. Mechanistic insight into ROS-mediated inflammation as a therapeutic target via targeting of DUOX
  6. Functional evaluation of osteopontin as a major pro-fibrotic factor post-MI

 

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Our Team