CRM Pump-Priming Funding

BHF Oxbridge Centre of Regenerative Medicine (CRM) has a pump-priming budget to support innovative ideas that need to produce preliminary data before submitting a project grant application to an external funding body.

Since 2014 there have been four rounds of pump-priming funding and the Centre has allocated nearly £700,000 of its budget. Decisions are always taken after external peer review of the applications.

There are no plans for any further calls for new pump-priming proposals.

Details of the projects funded under CRM1 and CRM2 are listed below.

Name	Location	Title	Award	Call
				2019
Nicola Smart	Oxford	Asymmetric cell division in the epicardium: a novel target for regeneration?	£41,700
Tilly Mommersteeg	Oxford	Comparing heart regeneration versus scarring on single cell level	£30,568
*Shoumo Bhattacharya*	Oxford	Characterisation of the chemokine network in myocardial infarction	£19,668
*Martin Bennett*	Cambridge	Rejuvenating aged intra-myocardial arteries after myocardial infarction	£46,700
*Helle Jorgensen*	Cambridge	Transcriptional profiling of single cells from human arteries to identify primed/progenitor cell populations	£25,310
*Rebecca Richardson*	Bristol	Validation of cardiomyocyte specific gene expression in macrophages after cardiac injury	£43,954
*Kim Mace*	Manchester	Reversing chronic inflammation through modulation of reactive oxygen species	£15,000
*Jurgen Schneider*	Leeds	Development of advanced MR imaging techniques for the regenerating mouse heart	£49,988
				2016
*Shoumo Bhattacharya*	Oxford	Targeting cardiac inflammation in post-infarction myocardial injury using novel chemokine-ligand traps derived from tick saliva	£20,474
*Nicola Smart*	Oxford	Generating new transgenic models to study the coronary vasculature	£24,595
*Paul Martin*	Bristol	Development of novel zebrafish models to analyse endogenous extracellular vesicle trafficking during the cardiac injury response and subsequent regeneration	£28,118
*Helle Jorgensen*	Cambridge	Investigation of vascular smooth muscle cell heterogeneity	£22,910
				2015
*Jurgen Schneider*	Oxford	Tracking stem cells in the living myocardium using 19F-MRI - a new paradigm for optimising preclinical studies	£29,995
Tilly Mommersteeg	Oxford	Heart regeneration: is it in the blood?	£29,960
Nicola Smart	Oxford	Sulfatases: novel targets for enhancing regeneration by epicardium-derived cells?	£17,472
Shankar Srinivas	Oxford	Characterising the initiation of coordinated calcium transients in the developing heart	£27,617
Paul Martin	Bristol	Development of novel software for live imaging inflammatory cell interactions in the beating heart	£16,281
Helle Jorgensen	Cambridge	Developing a Crispr/Cas9-mediated system for regulation of local chromatin configuration	£23,678
Amer Rana	Cambridge	Modelling cardiomyocyte biology in pulmonary arterial hypertension using induced pluripotent stem cells	£23,100
				2014
*Shoumo Bhattacharya*	Oxford	Targeting RASopathic fibrosis signalling pathways using monobodies	£17,900
*David Greaves*	Oxford	CD68-Luciferase reporter mice for in vivo imaging of monocyte recruitment in repair	£26,000
*Nicola Smart*	Oxford	SRSF3: a novel splicing regulator of epicardial gene networks?	£12,738
*Helle Jorgensen*	Cambridge	In vivo proliferation of vascular smooth muscle cells	£22,479
*Roger Pedersen*	Cambridge	Generation of human pluripotent stem cell lines capable of reporting cardiac chamber-specific differentiation	£27,922